DNA-based extracellular traps (yellow) released by neutrophils ensare extracellular tachyzoites (red)

Complete list of publications is available on PubMed

Initiation of Immunity

Gazzinelli, R.T. and E.Y. Denkers. 2006. Protozoan encounters with Toll-like receptor signaling pathways: Implications for host parasitism. Nat. Rev. Immunol. 6: 895-906. 

Cohen, S.B., Maurer, K.J., Egan, C.E., Oghumu, S., Satoskar, A.R., and E.Y. Denkers. 2013. CXCR3-dependent CD4+ T cells are required to activate inflammatory monocytes for defense against intestinal infection. PLoS-Pathogens. 9: e1003706.

Cohen, S.B. and E.Y. Denkers. 2014. Border maneuvers: Deployment of mucosal immune defenses against Toxoplasma gondii. Mucosal Immunol. doi: 10.1038/mi.2014.25.

Cohen, S.B., Pepper, M., Shah, S., Yap, G.S., Jiang, A., Clausen, B.E., and E.Y. Denkers. 2015. b-catenin signaling drives differentiation and function of IRF8-dependent dendritic cells. J. Immunol. 194: 210-222.

Cohen, S.B., and E.Y. Denkers. 2015. Impact of Toxoplasma gondii on dendritic cell subset function in the intestinal mucosa. J. Immunol. 195: 2754-2762

Immunopathology during infection

Egan, C. E., Craven, M. D., Leng, J., Simpson, K. W., and E. Y. Denkers. 2009. CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection. Mucosal Immunol. 2:527-535.

Egan, C. E., Maurer, K. J., Cohen, S. B., Mack, M., Davis, F. C., Simpson, K. W., and E. Y. Denkers. 2011. Synergy Between Intraepithelial Lymphocytes and Lamina Propria T Cells Drives Inflammation During Intestinal Infection. Mucosal Immunol. 4: 658-670

Craven, M. D., Egan, C. E., Dogan, B., Denkers, E., McDonough, S., Scherl, E. J., and K.W. Simpson. 2012. Acute intestinal inflammation decreases microbial diversity and triggers the proliferation of adherent and invasive E. coli. PLoS-One. 7:e41594

Egan, C. E., Cohen, S. B. and E. Y. Denkers. 2012. Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger. Immunol Cell Biol. 90:668-675.

Hijacking host cell intracellular signaling

Butcher, B.A., Kim, L., Murray, P.J., and E.Y. Denkers. 2005. Cutting Edge: IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-a in host macrophages. J. Immunol. 174: 3148-3152.

Kim, L. and E.Y. Denkers. 2006. Toxoplasma gondii triggers Gi-dependent phosphatidylinositol 3-kinase activation resulting in protein kinase B/Akt activation and inhibition of host cell apoptosis. J. Cell Sci. 119: 2119-2126.

Butcher, B. A., Fox, B. A., Rommereim, L. M., Kim, S. G., Maurer, K. J., Yarovinsky, F., Herbert, D. R., Bzik, D. J., and E. Y. Denkers. 2011. Toxoplasma gondii rhoptry protein ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control. PLoS-Pathogens. 7: e1002236.

Denkers, E.Y. and B.A. Butcher. 2012. Toxoplasma gondii parasites take control within host cells. Microbe 7: 360-365.

Denkers, E.Y., Bzik, D. J., Fox, B. A. and Butcher, B. A. 2012. An inside job: Hacking into JAK/STAT signaling cascades by the intracellular protozoan Toxoplasma gondii. Infect. Immun. 80: 476-482

Schneider, A.G., Abi Abdallah, D.S., Butcher, B.A., and E.Y. Denkers. 2013. Toxoplasma gondii Triggers Phosphorylation and Nuclear Translocation of Dendritic Cell STAT1 While Simultaneously Blocking IFNg-Induced STAT1 Transcriptional Activity. PLoS One 8: e20615.