DNA-based extracellular traps (yellow) released by neutrophils ensare extracellular tachyzoites (red)
|
|
Complete list of publications is available on PubMed
Initiation of Immunity
Gazzinelli, R.T. and E.Y. Denkers. 2006. Protozoan encounters with Toll-like receptor signaling pathways: Implications for host parasitism. Nat. Rev. Immunol. 6: 895-906.
Cohen, S.B., Maurer, K.J., Egan, C.E., Oghumu, S., Satoskar, A.R., and E.Y. Denkers. 2013. CXCR3-dependent CD4+ T cells are required to activate inflammatory monocytes for defense against intestinal infection. PLoS-Pathogens. 9: e1003706. Cohen, S.B. and E.Y. Denkers. 2014. Border maneuvers: Deployment of mucosal immune defenses against Toxoplasma gondii. Mucosal Immunol. doi: 10.1038/mi.2014.25. Cohen, S.B., Pepper, M., Shah, S., Yap, G.S., Jiang, A., Clausen, B.E., and E.Y. Denkers. 2015. b-catenin signaling drives differentiation and function of IRF8-dependent dendritic cells. J. Immunol. 194: 210-222. Cohen, S.B., and E.Y. Denkers. 2015. Impact of Toxoplasma gondii on dendritic cell subset function in the intestinal mucosa. J. Immunol. 195: 2754-2762 |
Immunopathology during infection Egan, C. E., Craven, M. D., Leng, J., Simpson, K. W., and E. Y. Denkers. 2009. CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection. Mucosal Immunol. 2:527-535.
Egan, C. E., Maurer, K. J., Cohen, S. B., Mack, M., Davis, F. C., Simpson, K. W., and E. Y. Denkers. 2011. Synergy Between Intraepithelial Lymphocytes and Lamina Propria T Cells Drives Inflammation During Intestinal Infection. Mucosal Immunol. 4: 658-670 Craven, M. D., Egan, C. E., Dogan, B., Denkers, E., McDonough, S., Scherl, E. J., and K.W. Simpson. 2012. Acute intestinal inflammation decreases microbial diversity and triggers the proliferation of adherent and invasive E. coli. PLoS-One. 7:e41594 Egan, C. E., Cohen, S. B. and E. Y. Denkers. 2012. Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger. Immunol Cell Biol. 90:668-675. |
Hijacking host cell intracellular signalingButcher, B. A., Fox, B. A., Rommereim, L. M., Kim, S. G., Maurer, K. J., Yarovinsky, F., Herbert, D. R., Bzik, D. J., and E. Y. Denkers. 2011. Toxoplasma gondii rhoptry protein ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control. PLoS-Pathogens. 7: e1002236.
Denkers, E.Y. and B.A. Butcher. 2012. Toxoplasma gondii parasites take control within host cells. Microbe 7: 360-365. Denkers, E.Y., Bzik, D. J., Fox, B. A. and Butcher, B. A. 2012. An inside job: Hacking into JAK/STAT signaling cascades by the intracellular protozoan Toxoplasma gondii. Infect. Immun. 80: 476-482 Schneider, A.G., Abi Abdallah, D.S., Butcher, B.A., and E.Y. Denkers. 2013. Toxoplasma gondii Triggers Phosphorylation and Nuclear Translocation of Dendritic Cell STAT1 While Simultaneously Blocking IFNg-Induced STAT1 Transcriptional Activity. PLoS One 8: e20615. Menard, K.L., Haskins, B.E., Columbo, A.P. and E.Y. Denkers. 2018. Toxoplasma gondii manipulates expression of host long noncoding RNA during intracellular infection. Sci. Rep. doi: 10.1038/s41598-018-33274-5 |