Complete list of publications is available on PubMed
Initiation of Immunity
Cohen, S.B. and E.Y. Denkers. 2014. Border maneuvers: Deployment of mucosal immune defenses against Toxoplasma gondii. Mucosal Immunol. doi: 10.1038/mi.2014.25.
Cohen, S.B., Pepper, M., Shah, S., Yap, G.S., Jiang, A., Clausen, B.E., and E.Y. Denkers. 2015. b-catenin signaling drives differentiation and function of IRF8-dependent dendritic cells. J. Immunol. 194: 210-222. Cohen, S.B., and E.Y. Denkers. 2015. Impact of Toxoplasma gondii on dendritic cell subset function in the intestinal mucosa. J. Immunol. 195: 2754-2762 Snyder, L.M. and E.Y. Denkers. 2021. From initiators to effectors: Roadmap through the intestine during encounter of Toxoplasma gondii with the mucosal immune system. Front Cell Infect Microbiol. 2021 Jan 11;10:614701. Snyder, L.M., Doherty, C.M., Mercer, H.L., and E.Y. Denkers. 2021. Induction of IL-12p40 and type 1 immunity by Toxoplasma gondii in the absence of the TLR-MyD88 signaling cascade. PLoS Pathog. 2021 Oct 1;17(10):e1009970. Doherty, C.M., Romero, A.D., and E.Y. Denkers. 2022. Impact of IFN-g and CD40 signaling on Toxoplasma gondii cyst formation in differentiated Neuro-2a neuroblastoma cells. Parasite Immunol. 2022 Jan;44(1-2):e12897. Snyder, L.M, Belmares-Ortega J., Doherty C.M., and E.Y. Denkers. 2022. Impact of MyD88, microbiota, and location on Type 1 and Type 3 innate lymphoid cells during Toxoplasma gondii infection. Immunohorizons. 2022 Sep 12;6(9):660-670. |
Immunopathology during infectionEgan, C. E., Craven, M. D., Leng, J., Simpson, K. W., and E. Y. Denkers. 2009. CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection. Mucosal Immunol. 2:527-535.
Egan, C. E., Maurer, K. J., Cohen, S. B., Mack, M., Davis, F. C., Simpson, K. W., and E. Y. Denkers. 2011. Synergy Between Intraepithelial Lymphocytes and Lamina Propria T Cells Drives Inflammation During Intestinal Infection. Mucosal Immunol. 4: 658-670 Craven, M. D., Egan, C. E., Dogan, B., Denkers, E., McDonough, S., Scherl, E. J., and K.W. Simpson. 2012. Acute intestinal inflammation decreases microbial diversity and triggers the proliferation of adherent and invasive E. coli. PLoS-One. 7:e41594 Egan, C. E., Cohen, S. B. and E. Y. Denkers. 2012. Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger. Immunol Cell Biol. 90:668-675. |
Hijacking host cell intracellular signalingDenkers, E.Y., Bzik, D. J., Fox, B. A. and Butcher, B. A. 2012. An inside job: Hacking into JAK/STAT signaling cascades by the intracellular protozoan Toxoplasma gondii. Infect. Immun. 80: 476-482
Schneider, A.G., Abi Abdallah, D.S., Butcher, B.A., and E.Y. Denkers. 2013. Toxoplasma gondii Triggers Phosphorylation and Nuclear Translocation of Dendritic Cell STAT1 While Simultaneously Blocking IFNg-Induced STAT1 Transcriptional Activity. PLoS One 8: e20615. Menard, K.L., Haskins, B.E., Columbo, A.P. and E.Y. Denkers. 2018. Toxoplasma gondii manipulates expression of host long noncoding RNA during intracellular infection. Sci. Rep. doi: 10.1038/s41598-018-33274-5 Menard, K.L., Haskins, B.E. and E.Y. Denkers. 2019. Impact of Toxoplasma gondii on host long noncoding RNA responses. Front. Cell. Infect. Microbiol. doi: 10.3389/fcimb.2019.00132. Mercer, H.L., Snyder, L.M., Doherty, C.M., Fox, B.A., Bzik, D.J., and E.Y. Denkers. 2020. Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity. PLoS-Pathogens. 16(5):e1008572. Menard K.L., Bu L., Denkers, E.Y. 2021. Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88. BMC Genomics. 2021 Feb 23;22(1):130. |